When I was stuck on my Ira Sargent, there were two families I focused on. I was "certain" he fit into one of them. Both families had several members named Ira--there had to be one that was "missing." They had the same general migration pattern, the age was consistent, etc. etc.
Turns out my Ira didn't belong to either one. And that his family really didn't live where he settled at all. The "other" families may be related, but it is so distant as to not really be relevant.
Sometimes similar names and places are coincidences. Just keep that in mind.