I've been working on a relative who was married at least 6 times. To help keep myself organized, I made charts for:
her marriages
where she was in each census year
what each census enumeration said about her
what years she had what last names
who was the father of what children
Just organizing the information about her helped me keep everything straight in my own mind.
The relative will be featured in an upcoming issue of Casefile Clues.