Some ancestors are more "portable" than others. Their lifestyle, economic status, and occupation can make it easier for them to pick up and move. Stop and think about how easy or difficult it would have been for your relative to simply move.
And if they did move, what records might they have left behind as a part of the moving process? Would there be records documenting the move? Land records may reference a new residence for an ancestor, especially if the sale of property was finalized after the move had taken place.