I have a family that moved from Virginia into Kentucky around 1800. The interesting thing is that the names of neighboring families to my ancestors in 1750 Virginia are the same names I see as their 1850 Kentucky neighbors in 1850.
I've got another set of German families that essentially "transplanted" a village from northern Germany to Illinois in the mid to late 1800s.
Some people tend to stick together even when they move. Use this to your advantage in your research.