If you have lost a female relative, have you considered whether or not they are really lost at all? They may simply be "hiding" under a new last name due to a marriage. If the time frame is after the 1850 US census, or any census that names all household members, look at the wives in nearby households. Is there one that has a female with the name of the "missing" person who has the age to be the missing person.
It may be that what you are missing is simply the marriage record.
Checking neighbors is a great way to find missing females (and sometimes males with misspelled names). I have found more than a few "missing" females and their married names and families doing this.
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